Key result
Epsilon-sarcoglycan replaces alpha-sarcoglycan as an integral component of the smooth muscle dystrophin-glycoprotein complex, which was restored following recombinant delta-sarcoglycan adenovirus injection.
Demonstrates a tissue-dependent variation in the sarcoglycan complex where epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle, providing a molecular basis for smooth muscle dysfunction in sarcoglycan-deficient patients.
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Does not yet alter clinical management; leaves open delta-sarcoglycan gene therapy for smooth muscle dysfunction pending human validation.
Straub et al. (1999) studied Muscular dystrophy and cardiomyopathy. Intramuscular injection of recombinant delta-sarcoglycan adenovirus was evaluated on Restoration of the smooth muscle sarcoglycan complex. Epsilon-sarcoglycan replaces alpha-sarcoglycan as an integral component of the smooth muscle dystrophin-glycoprotein complex, which was restored following recombinant delta-sarcoglycan adenovirus injection.
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