Key result
ACE and MTHFR gene polymorphisms were significantly associated with type 2 diabetes mellitus with dyslipidemia (P<0.001 and P=0.008, respectively).
Case-Control (n=559)
No
p-value: p=<0.001
ACE and MTHFR gene polymorphisms are significantly associated with the development of dyslipidemia in patients with type 2 diabetes mellitus.
These polymorphisms may flag dyslipidemia risk in T2DM but should not change practice; leaves open causal validation in prospective studies.
genes might be further associated with the development of dyslipidemia in T2DM cases.
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Raza et al. (2017) conducted a case-control in Type 2 Diabetes Mellitus with and without Dyslipidemia (n=559). ACE, FABP2, MTHFR, and FTO gene polymorphisms vs. Healthy controls and T2DM without dyslipidemia was evaluated on Association of ACE gene polymorphism with T2DM with dyslipidemia (p=<0.001). ACE and MTHFR gene polymorphisms were significantly associated with type 2 diabetes mellitus with dyslipidemia (P<0.001 and P=0.008, respectively).
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