Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2010Indian journal of human geneticsOpen Access

Null association between ACE gene I/D polymorphism and diabetic nephropathy among multiethnic Malaysian subjects

View Full Paper
Ask AI
Bookmark
Share

Key result

The ACE gene I/D polymorphism showed no significant association with type 2 diabetes or diabetic nephropathy in a multiethnic Malaysian population.

Why the study?

Does the ACE gene I/D polymorphism associate with the development of type 2 diabetes mellitus or diabetic nephropathy in a multiethnic Malaysian population?

Population

393 subjects, multiethnic Malaysian population. T2DM patients were subdivided by nephropathy status.

Comparison

Angiotensin Converting Enzyme insertion-deletion… vs Healthy controls and T2DM patients without…

Design

Case-control

Authors

SMSekaran MuniandyUniversiti Tenaga NasionalSCS P ChanUniversity of MalayaJJJaime Jacqueline JayapalanUniversity of Malaya

Discussion

Loading...

Member takes

Implication

No association in Malaysian cohort; does not support ACE I/D genotyping for T2DM risk and leaves broader applicability open.

Study Design

Type

Case-Control (n=393)

Multicenter

No

Structured PICO

Does the ACE gene I/D polymorphism associate with the development of type 2 diabetes mellitus or diabetic nephropathy in a multiethnic Malaysian population?

P
Population
393 multiethnic Malaysian adults, comprising 137 healthy controls and 256 patients with type 2 diabetes and varying stages of nephropathy, evaluated for genetic susceptibility.
E
Exposure
Angiotensin Converting Enzyme (ACE) insertion-deletion (I/D) gene polymorphism
C
Comparator
Healthy controls (for T2DM susceptibility) and T2DM patients without significant nephropathy (for diabetic nephropathy progression)
O
Outcome
Association of ACE I/D gene polymorphism with T2DM and diabetic nephropathysurrogate

Main Result

p-value: p=>0.05

The ACE gene I/D polymorphism is not significantly associated with type 2 diabetes mellitus or diabetic nephropathy in the multiethnic Malaysian population.

Limitations

  • Need for a more stringent case definition of diabetic nephropathy
  • Need for a larger sample size to elucidate the association in the Chinese ethnic group
  • Potential technical or methodological errors causing discrepancies compared to other studies
  • Small sample size requiring further extension to confirm and validate findings

Cite This Study

Muniandy et al. (2010) conducted a case-control in Diabetic nephropathy (n=393). ACE gene I/D polymorphism vs. Healthy controls and T2DM patients without nephropathy was evaluated on Association between ACE I/D genotype and susceptibility to T2DM or diabetic nephropathy (p=>0.05). The ACE gene I/D polymorphism showed no significant association with type 2 diabetes or diabetic nephropathy in a multiethnic Malaysian population.

synapsesocial.com/papers/6a9430fcbbea1c735e92dbc8https://doi.org/10.4103/0971-6866.69351
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymorphism of the ACE Gene in Dialysis Patients: Overexpression of DD Genotype in Type 2 Diabetic End-Stage Renal Failure Patients2005 · 23 citations
  2. 2Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients2004 · 55 citations
  3. 3Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects2008 · 62 citations
  4. 4ACE Variants Interact with the RAS Pathway to Confer Risk and Protection against Type 2 Diabetic Nephropathy2008 · 68 citations
  5. 5Prognostic Effect of Insertion/Deletion Polymorphism of the ACE Gene on Renal and Cardiovascular Clinical Outcomes in Chinese Patients With Type 2 Diabetes2005 · 54 citations