Key result
Recipient ACE (I/D) genotype D-allele was associated with shorter time to graft loss in high-risk subgroups with creatinine clearance <50 ml/min (P=0.017) or proteinuria ≥0.5 g/24 h (P=0.0051).
Why the study?
Is donor or recipient ACE (I/D) genotype associated with graft loss after renal transplantation?
Population
367 patients who underwent renal transplantation between 1987 and 1994 with at least 2 years of follow-up
Design
Cohort
Follow-up
mean 58 months
Authors
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May inform risk stratification in high-risk renal transplant recipients; leaves open whether genotyping improves outcomes.
Cohort (n=367)
Is donor or recipient ACE (I/D) genotype associated with graft loss after renal transplantation?
The recipient ACE (I/D) genotype D-allele is associated with faster graft loss in renal transplant patients who have concurrent risk factors such as reduced creatinine clearance or proteinuria.
Broekroelofs et al. (1998) conducted a cohort in Renal transplantation (n=367). Donor or recipient ACE (I/D) genotype was evaluated on Graft survival. Recipient ACE (I/D) genotype D-allele was associated with shorter time to graft loss in high-risk subgroups with creatinine clearance <50 ml/min (P=0.017) or proteinuria ≥0.5 g/24 h (P=0.0051).
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