Key result
The NSNA mutant virus showed a 7.8-fold increase in NS vRNA levels (p=0.002) and a 2.5-fold increase in NA vRNA levels (p<0.001) compared to the wild-type virus.
Population
MDCK cells infected with influenza A virus (A/WSN/33 strain)
Comparison
Recombinant influenza A viruses with NS… vs Wild-type influenza A virus and All-U mutant
Design
Preclinical
Follow-up
Up to 24 hours post-infection
Authors
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Hypothesis-generating for influenza vRNA interactions; leaves open any clinical or therapeutic relevance pending human studies.
Effect estimate: ~7.8 folds
p-value: p=0.002
Heterologous influenza vRNA segments with identical non-coding sequences can specifically stimulate viral RNA replication in trans.
Ng et al. (2008) studied Influenza A virus infection. NSNA mutant virus vs. Wild-type virus was evaluated on NS vRNA level (~7.8 folds, p=0.002). The NSNA mutant virus showed a 7.8-fold increase in NS vRNA levels (p=0.002) and a 2.5-fold increase in NA vRNA levels (p<0.001) compared to the wild-type virus.
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