Key result
Sequences at the ends of the coding regions of PB2, PB1, and PA vRNAs are critical for their incorporation into virions, with PB2 vRNA playing a primary hierarchical role in the incorporation of other segments.
Population
Influenza A virus strain A/WSN/33
Design
Preclinical
Authors
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Extends models of influenza segment hierarchy; hypothesis-generating for antiviral targeting in future studies.
The findings suggest a hierarchy among vRNA segments for virion incorporation, implying intersegment association during influenza A virus assembly.
Muramoto et al. (2006) studied Influenza A virus infection (in vitro). Mutant vRNA segments (PB2, PB1, PA) vs. Wild-type vRNA segments or other mutants was evaluated on Efficiency of infectious virion formation and vRNA virion incorporation. Sequences at the ends of the coding regions of PB2, PB1, and PA vRNAs are critical for their incorporation into virions, with PB2 vRNA playing a primary hierarchical role in the incorporation of other segments.
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