Key result
Highest tertiles of urinary HMW-beta TG and albumin excretion were associated with increased risk of coronary disease in middle-aged women (OR 2.4, 95% CI 1.1-5.0 and OR 2.1, 95% CI 1.0-4.1).
Why the study?
Are elevated urinary excretions of high molecular weight beta-thromboglobulin and albumin associated with subsequent coronary heart disease in middle-aged women?
Population
Middle-aged women from a breast cancer screening program cohort. The nested case-control study included 78…
Comparison
Highest tertile of urinary high molecular weight… vs Lowest tertile of urinary HMW-beta TG/creatinine…
Design
Case-control
Follow-up
median 5.1 years
Authors
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Hypothesis-generating for urinary markers in middle-aged women; prospective validation required before clinical adoption.
Case-Control (n=234)
Are elevated urinary excretions of high molecular weight beta-thromboglobulin and albumin associated with subsequent coronary heart disease in middle-aged women?
Odds Ratio: 2.4 (95% CI 1.1–5)
Increased urinary excretion of HMW-beta TG and albumin are independent predictors of subsequent coronary heart disease in middle-aged women, suggesting platelet activation and endothelial perturbation precede clinical events.
Gorgels et al. (1995) conducted a case-control in Coronary Heart Disease (n=234). Highest tertiles of urinary HMW-beta TG and albumin excretion vs. Lowest tertiles of urinary HMW-beta TG and albumin excretion was evaluated on Myocardial infarction or angiographically confirmed coronary disease (OR 2.4, 95% CI 1.1-5.0). Highest tertiles of urinary HMW-beta TG and albumin excretion were associated with increased risk of coronary disease in middle-aged women (OR 2.4, 95% CI 1.1-5.0 and OR 2.1, 95% CI 1.0-4.1).
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