Key result
The ketamine-propofol combination resulted in a significantly lower mean heart rate by 4.47 beats per minute compared to the ketamine-midazolam combination, with no significant difference in oxygen saturation.
Why the study?
Vital parameters must be monitored during sedation, prompting an evaluation of the effects of ketamine-midazolam versus ketamine-propofol combinations on heart rate and oxygen saturation in non-cooperative children.
Does ketamine-propofol compared to ketamine-midazolam improve heart rate and oxygen saturation in non-cooperative children undergoing dental procedures?
RCT (n=22)
Double-blind
Randomized sequence assignment
No
Does ketamine-propofol compared to ketamine-midazolam improve heart rate and oxygen saturation in non-cooperative children undergoing dental procedures?
Answers are grounded in this paper and cite their sources.
In non-cooperative children undergoing dental procedures, a ketamine-propofol combination resulted in a lower heart rate compared to ketamine-midazolam, with no difference in oxygen saturation.
Background: Vital parameters must be monitored during sedation. This study aimed to evaluate the effects of ketamine-midazolam (KM) and ketamine-propofol (KP) combinations on the heart rate (HR) and oxygen saturation (SPO2 ) of non-cooperative children. The model parameters were estimated using the Bayesian approach. Methods: The data were collected in a double-masked crossover study with repeated measurements (CSWRM). Twenty-two noncooperative children 3–6 years old were included, and the linear mixed model was adopted for data analysis. The Bayesian estimation of the parameters and their 95% credible interval were calculated in SAS 9.4. Results: The mean HR of KM recipients compared to KP recipients was significantly different by 4.47 beats per minute (bpm). The mean HR in KP was lower than KM’s, but SPO2 was not significantly different. Conclusion: Although the two drug combinations did not differ in SPO2 , they differed in HR. As such, the KP combination is recommended.
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Abbasi-Asl et al. (2024) conducted an RCT in Non-cooperative children requiring dental treatment (n=22). Ketamine-propofol (KP) vs. Ketamine-midazolam (KM) (2-0.2 mg/kg intravenously) was evaluated on Mean heart rate (HR) (MD -4.47 bpm, 95% CI -7.71 to -1.41, p=<0.05). The ketamine-propofol combination resulted in a significantly lower mean heart rate by 4.47 beats per minute compared to the ketamine-midazolam combination, with no significant difference in oxygen saturation.
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