Key result
Intrapericardial administration of Gelfoam loaded with periostin peptide in pigs after myocardial infarction led to a 6.5-fold increase in cardiomyocyte mitosis compared to control (p<0.001).
Why the study?
Does intrapericardial administration of Gelfoam loaded with recombinant peptide of Periostin (rPN) improve cardiomyocyte cell cycle activity and angiogenesis in a pig model of myocardial infarction?
Population
Preclinical models including mice and Yorkshire pigs with myocardial infarction induced by complete…
Comparison
Intrapericardial administration of Gelfoam disks… vs Direct injection of rPN alone, or Gelfoam with…
Design
Preclinical, Pathologist scored the degree of fibrosis and inflammation in a…
Follow-up
1 week and 12 weeks
Authors
Loading...
Hypothesis-generating for periostin delivery post-MI; leaves open human translation and requires clinical trials.
Does intrapericardial administration of Gelfoam loaded with recombinant peptide of Periostin (rPN) improve cardiomyocyte cell cycle activity and angiogenesis in a pig model of myocardial infarction?
Effect estimate: 6.5-fold increase
p-value: p=<0.001
Intrapericardial delivery of rPN via Gelfoam hydrogels prolongs its release and enhances cardiomyocyte cell cycle activity and angiogenesis in a swine model of myocardial infarction.
Polizzotti et al. (2012) studied Myocardial Infarction (n=13). Intrapericardial delivery of Gelfoam loaded with recombinant periostin peptide (rPN) vs. Gelfoam loaded with saline was evaluated on H3P-positive cardiomyocytes per millimeter squared at one week (6.5-fold increase, p=<0.001). Intrapericardial administration of Gelfoam loaded with periostin peptide in pigs after myocardial infarction led to a 6.5-fold increase in cardiomyocyte mitosis compared to control (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: