Key result
Administration of fresh frozen plasma and 4-factor prothrombin complex concentrate provided minimal benefit in reversing coagulation abnormalities caused by factor Xa inhibitors in three patients with intracranial hemorrhage.
Why the study?
Do fresh frozen plasma and 4-factor prothrombin complex concentrate reverse coagulation abnormalities in patients with intracranial hemorrhage taking oral factor Xa inhibitors?
Population
3 patients with intracranial hemorrhage taking oral factor Xa inhibitors
Design
Case_series
Authors
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Minimal reversal with FFP and 4F-PCC in factor Xa inhibitor ICH cases; hypothesis-generating and should not change practice without prospective data.
Case Report (n=3)
Do fresh frozen plasma and 4-factor prothrombin complex concentrate reverse coagulation abnormalities in patients with intracranial hemorrhage taking oral factor Xa inhibitors?
In life-threatening intracranial hemorrhage associated with factor Xa inhibitors, fresh frozen plasma and 4-factor prothrombin complex concentrate may offer minimal benefit but should be considered to prevent bleed progression.
Karli et al. (2015) conducted a case report in Intracranial hemorrhage (n=3). Fresh frozen plasma and 4-factor prothrombin complex concentrate was evaluated on Reversal of coagulation abnormalities and hematoma expansion. Administration of fresh frozen plasma and 4-factor prothrombin complex concentrate provided minimal benefit in reversing coagulation abnormalities caused by factor Xa inhibitors in three patients with intracranial hemorrhage.