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June 1, 2005Journal of Endovascular Therapy

Influence of Diabetes Mellitus on the Endovascular Treatment of Abdominal Aortic Aneurysms

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Key result

Diabetes mellitus was associated with a significantly higher risk of mortality compared to nondiabetic patients (13% vs 10%; OR 1.27, 95% CI 1.01-1.59, p<0.039) after endovascular AAA repair.

Why the study?

Does diabetes mellitus influence outcomes after endovascular abdominal aortic aneurysm repair?

Population

6,017 patients enrolled in the EUROSTAR registry after undergoing endovascular abdominal aortic aneurysm…

Comparison

Presence of diabetes mellitus vs Absence of diabetes mellitus

Design

Cohort

Follow-up

48 months

Authors

LLLina J. LeursRLRobert J.F. LaheijJBJacob Buth

Discussion

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Overview

May warrant closer perioperative monitoring in diabetic EVAR patients; leaves open whether the association is causal or modifiable.

Study Design

Type

Cohort (n=6,017)

Multicenter

Yes

Structured PICO

Does diabetes mellitus influence outcomes after endovascular abdominal aortic aneurysm repair?

P
Population
6,017 patients undergoing endovascular abdominal aortic aneurysm repair enrolled in the EUROSTAR registry, of whom 12% had diabetes mellitus, followed for up to 48 months.
E
Exposure
Presence of diabetes mellitus
C
Comparator
Absence of diabetes mellitus
O
Outcome
Device-related complications and mortalityhard clinical

Main Result

Odds Ratio: 1.27 (95% CI 1.01–1.59)

Absolute Event Rate: 13% vs 10%

p-value: p=< 0.039

Diabetes mellitus is associated with higher early mortality and device-related complications following endovascular AAA repair, but does not significantly impact long-term survival.

Cite This Study

Leurs et al. (2005) conducted a cohort in Abdominal aortic aneurysm (AAA) (n=6,017). Diabetes mellitus vs. Nondiabetic patients was evaluated on Mortality (OR 1.27, 95% CI 1.01 to 1.59, p=< 0.039). Diabetes mellitus was associated with a significantly higher risk of mortality compared to nondiabetic patients (13% vs 10%; OR 1.27, 95% CI 1.01-1.59, p<0.039) after endovascular AAA repair.

synapsesocial.com/papers/6a945c668a4c78aef331a3e7https://doi.org/10.1583/04-1260mr.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endovascular vs Open Abdominal Aortic Aneurysm Repair1999 · 43 citations
  2. 2Elective Endovascular versus Open Surgical Repair of Abdominal Aortic Aneurysms: Systematic Review of Short-term Results2002 · 138 citations
  3. 3Hyperglycemia and Arterial Disease1981 · 46 citations
  4. 4EPIDEMIOLOGY AND PUBLIC HEALTH ASPECTS OF NON-INSULIN-DEPENDENT DIABETES MELLITUS1989 · 101 citations
  5. 5Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes1994 · 489 citations