What question did this study set out to answer?

To determine the cardiovascular and cutaneous microcirculatory effects of intravenous adenosine infusion in healthy humans and evaluate whether dipyridamole potentiates these responses.

March 1, 1987Acta Physiologica Scandinavica

Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole

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Why the study?

Does dipyridamole potentiate the cardiovascular effects of infused adenosine in normal subjects?

Population

8 normal subjects (23-40 years)

Comparison

Adenosine as a constant i.v. infusion following… vs Adenosine as a constant i.v. infusion following…

Design

RCT, randomized, single blind

Authors

TCTB ConradsonLund University CDCM DixonLock Haven University BCB. F. ClarkeNHS Lothian

Discussion

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Implication

Dipyridamole markedly potentiates adenosine chronotropy, requiring dose reduction on coadministration; confirms interaction via RCT in healthy subjects.

Key Points

To determine the cardiovascular and cutaneous microcirculatory effects of intravenous adenosine infusion in healthy humans and evaluate whether dipyridamole potentiates these responses.
Conducted a single-blind randomized study in 8 healthy subjects aged 23–40 years across two separate testing days.
Administered escalating intravenous adenosine infusions (0.005–0.1 mg kg⁻¹ min⁻¹) following premedication with either intravenous dipyridamole (0.4 mg kg⁻¹ over 10 min) or a matched volume of saline.
Monitored heart rate, arterial blood pressure, and skin temperature continuously throughout infusions.
Following saline, adenosine increased heart rate in a dose-dependent manner, peaking at an increase of 16 ± 10 bpm (P < 0.01) and raising skin temperature by 1.3 ± 0.8 °C (P < 0.02) at 0.09 mg kg⁻¹ min⁻¹ without altering blood pressure.
Pretreatment with dipyridamole significantly potentiated adenosine, eliciting a 15 bpm heart rate increase at 0.005 mg kg⁻¹ min⁻¹ compared to the 0.08–0.09 mg kg⁻¹ min⁻¹ required following saline.

Structured PICO

Does dipyridamole potentiate the cardiovascular effects of infused adenosine in normal subjects?

Population

8 normal subjects (23-40 years)

Intervention

Adenosine as a constant i.v. infusion (0.005-0.1 mg kg-1 min-1) following i.v. dipyridamole 0.4 mg kg-1 per 10 min

Comparator

Adenosine as a constant i.v. infusion following a corresponding volume of saline

Outcome

Heart rate, blood pressure and skin temperaturesurrogate

Dipyridamole significantly potentiates the positive chronotropic and local dilatory effects of infused adenosine in healthy humans.

Cite This Study

Conradson et al. (1987) studied this question.

synapsesocial.com/papers/6a945cdefde2ed39e1a0d072 https://doi.org/10.1111/j.1748-1716.1987.tb08082.x

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Implication

Dipyridamole markedly potentiates adenosine chronotropy, requiring dose reduction on coadministration; confirms interaction via RCT in healthy subjects.

Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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