Key result
In pigs with hibernating myocardium, transient epinephrine infusion improved wall thickening (2.3 to 4.1 mm, P<0.05), whereas graded infusion did not, indicating dependence on the stimulation protocol.
Population
Pigs chronically instrumented with a left anterior descending coronary artery stenosis to produce…
Comparison
Graded beta-adrenergic stimulation and transient… vs Sham controls
Design
Preclinical
Authors
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Protocol-specific epinephrine responses in hibernating myocardium warrant caution in viability testing; hypothesis-generating for optimal protocols in clinical studies.
Variability in contractile reserve in hibernating myocardium depends on the protocol used for beta-adrenergic stimulation, with transient stimulation eliciting improved function compared to graded steady-state stimulation.
Brian Malm (2002) studied Hibernating myocardium. Epinephrine (beta-adrenergic stimulation) vs. Sham controls was evaluated on Subendocardial flow and wall thickening. In pigs with hibernating myocardium, transient epinephrine infusion improved wall thickening (2.3 to 4.1 mm, P<0.05), whereas graded infusion did not, indicating dependence on the stimulation protocol.
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