Key result
Slowly degradable HES solutions decrease coagulation factor VIII and von Willebrand factor and impair platelet reactivity, whereas rapidly degradable HES solutions have minimal effects on hemostasis.
Why the study?
Do different preparations of hydroxyethyl starch (HES) solutions have varying effects on hemostasis and coagulation factors?
Population
Patients requiring plasma expansion in perioperative situations, intensive care, and healthy volunteers
Design
Review
Authors
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May favor rapidly degradable HES perioperatively to limit hemostatic impairment; leaves open confirmation in outcome trials.
Do different preparations of hydroxyethyl starch (HES) solutions have varying effects on hemostasis and coagulation factors?
Slowly degradable HES solutions significantly impair hemostasis by decreasing factor VIII and vWF and inhibiting platelet function, whereas rapidly degradable HES solutions (like tetrastarches) minimize these antithrombotic side effects.
Sibylle A. Kozek‐Langenecker (2005) conducted a review in Perioperative bleeding risk and hemostasis. Hydroxyethyl starch (HES) solutions was evaluated. Slowly degradable HES solutions decrease coagulation factor VIII and von Willebrand factor and impair platelet reactivity, whereas rapidly degradable HES solutions have minimal effects on hemostasis.
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