Key result
Obesity increases the risk of severe COVID-19 complications and mortality through mechanisms involving chronic low-grade inflammation, adipose tissue dysfunction, and systemic microvascular endothelial dysfunction.
Why the study?
Although obesity is associated with COVID-19 severity, the mechanisms underlying the increased risk of complications and mortality in obese patients are of diverse nature.
Population
Obese patients with COVID-19
Design
Review
Authors
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May inform CV risk stratification in obese COVID-19 patients; leaves open targeted interventions pending prospective validation.
Obesity-related chronic inflammation and endothelial dysfunction provide a mechanistic link to the increased severity and cardiovascular complications observed in COVID-19 patients.
Lorenzo et al. (2021) conducted a review in COVID-19 and Obesity. Obesity vs. Non-obese was evaluated. Obesity increases the risk of severe COVID-19 complications and mortality through mechanisms involving chronic low-grade inflammation, adipose tissue dysfunction, and systemic microvascular endothelial dysfunction.
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