Key result
Pre-loading with 500 ml of 6% hydroxyethyl starch or 4% succinylated gelatine induced a mild hypocoagulable effect, with all TEG parameters remaining within or very close to the normal range.
Why the study?
Does pre-loading with hydroxyethyl starch versus succinylated gelatine affect thromboelastography parameters in healthy parturients prior to caesarean delivery?
RCT (n=50)
Double-blind
randomized
Does pre-loading with hydroxyethyl starch versus succinylated gelatine affect thromboelastography parameters in healthy parturients prior to caesarean delivery?
Pre-loading with either hydroxyethyl starch or succinylated gelatine prior to spinal anesthesia for cesarean section induces a mild hypocoagulable effect that remains clinically within normal limits.
Answers are grounded in this paper and cite their sources.
Supports safe colloid preloading before cesarean; provides RCT confirmation of minimal TEG impact in parturients.
This prospective, randomized, double-blind study compared the effects on thromboelastography (TEG) of pre-loading with two different colloid fluids prior to spinal anaesthesia for caesarean section. Healthy full-term parturients received either 500 ml 6% hydroxyethyl starch 130/0.4 (HES, n = 25) or 500 ml 4% succinylated gelatine (GEL, n = 25) prior to spinal anaesthesia. TEG parameters including reaction time (r-time), clot formation time (k-time), clot formation rate (α-angle) and maximum amplitude (MA) were measured immediately before and after pre-loading. Both groups had significantly shorter r-time and lower MA after pre-loading. The α-angle was significantly decreased after pre-loading with HES but not with GEL. No significant differences in k-time were induced pre-loading. In conclusion, pre-loading with HES or GEL was associated with a mild hypocoagulable effect in healthy parturients presenting for elective caesarean section; however, all TEG parameters in both groups remained within or very close to the normal range after pre-loading.
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Türker et al. (2011) conducted an RCT in Healthy full-term parturients presenting for elective caesarean section (n=50). 6% hydroxyethyl starch 130/0.4 (HES) vs. 4% succinylated gelatine (GEL) was evaluated on Thromboelastography (TEG) parameters including r-time, k-time, α-angle, and maximum amplitude. Pre-loading with 500 ml of 6% hydroxyethyl starch or 4% succinylated gelatine induced a mild hypocoagulable effect, with all TEG parameters remaining within or very close to the normal range.
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