Key result
Preloading with 6% Hetastarch significantly reduced the incidence of hypotension to 10% compared to 56.66% with Hartman's solution in pre-eclamptic patients undergoing caesarean section.
Why the study?
Does preloading with 6% Hetastarch compared to Hartman's solution reduce the incidence of hypotension in pre-eclamptic patients undergoing caesarean section under sub-arachnoid block?
RCT (n=60)
Double-blind
Blind envelop method
No
Does preloading with 6% Hetastarch compared to Hartman's solution reduce the incidence of hypotension in pre-eclamptic patients undergoing caesarean section under sub-arachnoid block?
Preloading with 6% Hetastarch significantly reduces the incidence of hypotension and the need for vasopressors compared to Hartman's solution in pre-eclamptic women undergoing cesarean section under spinal anesthesia.
Answers are grounded in this paper and cite their sources.
Supports 6% Hetastarch preloading to reduce hypotension in pre-eclamptic spinal cesarean sections; extends colloid evidence to this high-risk population.
When sub-arachnoid block is performed on preeclamptic mother, profound hypotension may occur. To maintain haemodynamic stability, patients can be preloaded with crystalloid or colloid solution. 60 pre-eclamptic pregnant mothers with ASA grade I & II were randomly divided into two equal groups by blind envelop method. In Group- A, patients were preloaded with Hartman's solutions @ 15ml/kg and in Group-B, with 6% Hetastarch @ 5ml/kg. The results of the study showed that hypotension was less in group-B (10%) than group-A (56.66%). Total additional volume of fluid required to treat hypotension was less in Group-B, (803.33ml) than Group-A (1526.66ml). Only three (3) cases of Group-B required ephedrine 0.83±2.65 mg) in comparison to 17 cases of Group- A (4.50±4.79 mg). So, it can be concluded that preloading of pre-eclamptic pregnant mothers with 6% Hetastarch is superior to Hartman's solution in caesarean section after sub-arachnoid block to maintain a stable haemodynamic status. Key words: HES; Pre-eclampsia; Subarachnoid block Journal of BSA, Vol. 17, No. 1 & 2, 2004 p.7-11DOI: http://dx.doi.org/10.3329/jbsa.v17i1.4044
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Islam et al. (2014) conducted an RCT in Pre-eclampsia (n=60). 6% Hetastarch vs. Hartman's solution (15 ml/kg) was evaluated on Incidence of hypotension (p=0.001). Preloading with 6% Hetastarch significantly reduced the incidence of hypotension to 10% compared to 56.66% with Hartman's solution in pre-eclamptic patients undergoing caesarean section.
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