Key result
Genetic predisposition, particularly polymorphisms in the renin-angiotensin system, is believed to contribute to the polygenic development and progression of diabetic nephropathy.
Diabetic nephropathy has a polygenic background, with renin-angiotensin system gene polymorphisms playing a potential role in its development and progression.
Supports genetic research in diabetic nephropathy; does not support clinical testing or risk stratification yet.
Diabetic nephropathy (DN) develops in approximately 40% of type 1 diabetic patients and is a leading cause of end-stage renal failure. Its rate of progression varies greatly among individuals. Several factors, including genetic predisposition, metabolic and haemodynamic alterations and various growth factors, may contribute to the initiation and progression of DN. The genetic background of DN is believed to be polygenic. Polymorphisms of different genes, mainly from the renin-angiotensin system, have been studied extensively, and some of them have been suggested to contribute to the development of DN. A search for genes and combinations of genes which could influence the development and progression of DN is in progress.
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M Merta (2003) conducted a review in Diabetic nephropathy. Genetic polymorphisms was evaluated. Genetic predisposition, particularly polymorphisms in the renin-angiotensin system, is believed to contribute to the polygenic development and progression of diabetic nephropathy.
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