Key result
Poliovirus RNA was detected in the peripheral blood lymphocytes (7 of 37) and cerebrospinal fluid (4 of 40) of patients with post-polio syndrome, but in none of the controls.
Why the study?
Is poliovirus infection associated with the development of post-polio syndrome?
Population
47 patients with post-polio syndrome (PPS)
Design
Case-control
Authors
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Poliovirus RNA detection supports persistence hypothesis in post-polio syndrome; hypothesis-generating and should not yet change practice.
Case-Control (n=47)
Is poliovirus infection associated with the development of post-polio syndrome?
The presence of IgM anti-PV antibodies and PV-RNA in some patients with post-polio syndrome suggests possible persistence of mutated virus or defective PV particles.
Leon‐Monzon et al. (1995) conducted a case-control in Post-polio syndrome (n=47). Poliovirus infection vs. Normal subjects or disease controls was evaluated on Detection of IgM PV antibodies and PV sequences. Poliovirus RNA was detected in the peripheral blood lymphocytes (7 of 37) and cerebrospinal fluid (4 of 40) of patients with post-polio syndrome, but in none of the controls.
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