Key result
Acetylsalicylic acid administered during a fish diet had an additive effect on decreasing platelet aggregability to ADP in healthy men.
Why the study?
Does acetylsalicylic acid combined with a fish diet reduce platelet aggregation more than either intervention alone in healthy men?
Does acetylsalicylic acid combined with a fish diet reduce platelet aggregation more than either intervention alone in healthy men?
The combination of acetylsalicylic acid and a fish diet has an additive effect on reducing platelet aggregation, suggesting a potential dietary augmentation of ASA's antithrombotic effects.
Should not yet change ASA or diet recommendations; hypothesis-generating for additive effects in healthy men.
The effect of acetylsalicylic acid (ASA) on platelet aggregation before and during a fish diet, already known to decrease the aggregability of platelets and to prolong the bleeding time, was studied in 10 healthy men. Two doses (3.5 and 10 mg/kg body weight) of ASA were given. Both doses equally decreased platelet aggregation to collagen and adenosine diphosphate (ADP). ASA, taken before the diet, diminished platelet aggregability to ADP by as much as did the diet alone. When ASA was administered during the diet, the effect on platelet aggregability to ADP was additive. Aggregation to collagen also decreased to the same extent as during the baseline period. The results, in conjunction with our earlier ones, indicate that the mechanism by which a fish diet delays primary haemostasis is different from the apparently similar effect of ASA. This raises the possibility of augmenting any antithrombotic effect of ASA by dietary means.
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Thorngren et al. (2009) studied Healthy (n=10). Acetylsalicylic acid (ASA) vs. Baseline / fish diet alone was evaluated on Platelet aggregation to collagen and adenosine diphosphate (ADP). Acetylsalicylic acid administered during a fish diet had an additive effect on decreasing platelet aggregability to ADP in healthy men.
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