Key result
Acetylsalicylic acid inhibited platelet aggregation with a lower IC50 in whole blood than in platelet-rich plasma, and required higher concentrations for half-maximal inhibition in females.
Why the study?
Does acetylsalicylic acid inhibit platelet aggregation differently in whole blood compared to platelet-rich plasma in male and female healthy volunteers?
Population
Blood samples from 24 male and 24 female healthy volunteers (n=48)
Comparison
Acetylsalicylic acid (ASA) in whole blood (WB) vs Acetylsalicylic acid in platelet-rich plasma
Design
Preclinical
Authors
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Hypothesis-generating for sex differences in aspirin potency by assay; animal data leave clinical translation open.
Does acetylsalicylic acid inhibit platelet aggregation differently in whole blood compared to platelet-rich plasma in male and female healthy volunteers?
Acetylsalicylic acid inhibits platelet aggregation more potently in whole blood than in platelet-rich plasma, with females requiring higher concentrations for half-maximal inhibition than males.
Cruz et al. (1986) studied healthy volunteers (n=48). acetylsalicylic acid (ASA) vs. platelet-rich plasma (PRP) was evaluated on IC50 of platelet aggregation. Acetylsalicylic acid inhibited platelet aggregation with a lower IC50 in whole blood than in platelet-rich plasma, and required higher concentrations for half-maximal inhibition in females.
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