Key result
5-nitrocytidine was effective against poliovirus and coxsackievirus B3, exhibiting greater activity than ribavirin by inhibiting viral RNA-dependent RNA polymerase (Kd = 1.1 +/- 0.1 microM).
Why the study?
Does 5-nitrocytidine inhibit poliovirus and coxsackievirus B3 compared to ribavirin?
Does 5-nitrocytidine inhibit poliovirus and coxsackievirus B3 compared to ribavirin?
5-nitrocytidine is a potent inhibitor of viral RNA-dependent RNA polymerases with greater in vitro activity against poliovirus and coxsackievirus B3 than ribavirin.
Answers are grounded in this paper and cite their sources.
May advance enterovirus antiviral leads; leaves open clinical translation pending human studies.
As part of our studies of lethal viral mutagens, a series of 5-substituted cytidine analogues were synthesized and evaluated for antiviral activity. Among the compounds examined, 5-nitrocytidine was effective against poliovirus (PV) and coxsackievirus B3 (CVB3) and exhibited greater activity than the clinically employed drug ribavirin. Instead of promoting viral mutagenesis, 5-nitrocytidine triphosphate inhibited PV RNA-dependent RNA polymerase (K(d) = 1.1 +/- 0.1 microM), and this inhibition is sufficient to explain the observed antiviral activity.
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Harki et al. (2006) studied Poliovirus and coxsackievirus B3 infection. 5-nitrocytidine vs. ribavirin was evaluated on Inhibition of PV RNA-dependent RNA polymerase (K(d) = 1.1 +/- 0.1 microM). 5-nitrocytidine was effective against poliovirus and coxsackievirus B3, exhibiting greater activity than ribavirin by inhibiting viral RNA-dependent RNA polymerase (Kd = 1.1 +/- 0.1 microM).
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