B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation
Key result
Admission B-type natriuretic peptide demonstrated significantly higher sensitivity for acute myocardial infarction (70.8%) than CKMB (45.8%) and troponin-I (50.7%) (P<0.0001).
Why the study?
Does admission B-type natriuretic peptide (BNP) testing improve the diagnosis of acute myocardial infarction in patients with acute chest pain and no ST-segment elevation?
Population
631 consecutive patients presenting to the emergency department with acute chest pain and no ST-segment…
Comparison
Admission B-type natriuretic peptide (BNP) testing vs Creatine kinase-MB (CKMB) and troponin-I
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
May support admission BNP as adjunct for AMI diagnosis in non-ST-elevation chest pain; leaves open need for prospective outcome trials before practice change.
Study Design
Type
Observational (n=631)
Structured PICO
Does admission B-type natriuretic peptide (BNP) testing improve the diagnosis of acute myocardial infarction in patients with acute chest pain and no ST-segment elevation?
P
Population
631 consecutive patients presenting to the emergency department with acute chest pain and no ST-segment elevation.
E
Exposure
Admission B-type natriuretic peptide (BNP) testing
C
Comparator
Creatine kinase-MB (CKMB) and troponin-I
O
Outcome
Diagnostic sensitivity and specificity for acute myocardial infarction (AMI)surrogate
Main Result
Absolute Event Rate: 70.8% vs 45.8%
p-value: p=<0.0001
Admission BNP is a useful adjunct to standard cardiac markers for diagnosing AMI in patients with chest pain and no ST-segment elevation, particularly when initial markers are non-diagnostic.
Cite This Study
Bassan et al. (2004) conducted an observational in Acute chest pain with no ST-segment elevation (n=631). Admission B-type natriuretic peptide (BNP) vs. Creatine kinase-MB (CKMB) and troponin-I was evaluated on Sensitivity for acute myocardial infarction (p=<0.0001). Admission B-type natriuretic peptide demonstrated significantly higher sensitivity for acute myocardial infarction (70.8%) than CKMB (45.8%) and troponin-I (50.7%) (P<0.0001).