Key result
Atrial fibrillation in hospitalized patients with multimorbidity was associated with higher unadjusted mortality but was not independently associated with mortality overall.
Why the study?
Patients hospitalized with AF commonly have comorbidities, but few studies have determined prognostic factors for mortality in hospitalized AF patients with multimorbidity.
Cohort (n=52,939)
No
Answers are grounded in this paper and cite their sources.
BACKGROUND: Patients with atrial fibrillation (AF) admitted to hospital commonly have comorbidities. Few studies have attempted to determine factors prognostic of mortality in hospitalized AF patients with multimorbidity. AIM: To identify factors associated with mortality in hospitalized AF patients. DESIGN: Retrospective cohort study. METHODS: Patients with multimorbidity (≥2 chronic diseases), with or without AF, discharged from Lugo hospital (Spain) between 1 January 2000 and 31 December 2015. Data were extracted from hospital medical records. RESULTS: Of 74 220 patients (170 978 hospitalizations), 52 939 had multimorbidity (14 181 had AF; 38 758 no AF) and were included in our study. Patients with AF were older (mean ± standard deviation 78.6 ± 10.0 vs. 71.9 ± 14.2 years) and had a higher mortality rate (27.1 vs. 20.5%) than those without AF. Gender (female), age, stroke and congestive heart failure (CHF), but not AF, were independently associated with mortality. AF significantly increased the mortality risk in women [relative risk (RR) 1.091; 95% confidence interval (CI) 1.021-1.165; P = 0.010] and in those aged >80 years (RR 1.153; 95% CI, 1.1-1.2; P < 0.001). CHF independently increased the risk of mortality across all age groups (RR 1.496; 95% CI 1.422-1.574; P < 0.001). CONCLUSIONS: Hospitalized patients with AF have a higher mortality rate than those without AF. The prognostic significance of AF changes with age and gender while CHF is associated with the greatest risk of death.
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Vázquez et al. (2019) conducted a cohort in Multimorbidity with or without atrial fibrillation (n=52,939). Atrial fibrillation vs. No atrial fibrillation was evaluated on mortality. Atrial fibrillation in hospitalized patients with multimorbidity was associated with higher unadjusted mortality but was not independently associated with mortality overall.
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