Key result
CUG repeats in the myotonin kinase gene transcript form metastable 'slippery' hairpins, with stability increasing from 11 to 49 repeats, potentially contributing to myotonic dystrophy pathogenesis.
Authors
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No immediate clinical implications for myotonic dystrophy; leaves open whether repeat stability offers viable therapeutic targets.
Напиерала et al. (1997) studied Myotonic dystrophy. CUG repeats in myotonin kinase RNA was evaluated on RNA secondary structure formation. CUG repeats in the myotonin kinase gene transcript form metastable 'slippery' hairpins, with stability increasing from 11 to 49 repeats, potentially contributing to myotonic dystrophy pathogenesis.
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