Key result
The Ala67Thr mutation in the PVR gene was detected in 45.46% of patients with progressive post-polio syndrome compared to 10% of normal controls.
Why the study?
Is the Ala67Thr mutation in the PVR gene associated with the development of post-polio syndrome?
Case-Control (n=310)
Is the Ala67Thr mutation in the PVR gene associated with the development of post-polio syndrome?
The Ala67Thr mutation in the PVR gene is significantly associated with post-polio syndrome, suggesting a genetic susceptibility to progressive cytopathic effects.
Answers are grounded in this paper and cite their sources.
May support genetic susceptibility in post-polio syndrome; leaves open validation in larger prospective studies before clinical use.
Poliovirus (PV) has been implicated in the etiology of poliomyelitis. Post-polio syndrome (PPS) is a condition that affects polio survivor years after recovery from an initial acute attack of the polio virus. DNA polymorphisms in the poliovirus receptor gene (PVR) are associated with persistent poliovirus infection. In the present study we have presented clinical and demographic characteristics of the PPS individuals who were affected initially by poliomyelitis and later developed PPS. We have also attempted to find out whether mutation in the PVR gene allows poliomyelitis patients to progress for PPS. PVR mutation was studied in 110 cases of PPS and 200 normal controls. In PVR exon 2, the Ala67Thr mutation was detected in 45.46% of progressive PPS and 10% of control subjects. The frequency of the mutation was significantly higher in patients with PPS than in controls. Changes in the PVR gene may result in slowly progressive cytopathic effects that may lead to progression of PPS.
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S Bhattacharya (2014) conducted a case-control in Post-polio syndrome (PPS) (n=310). Ala67Thr mutation in the PVR gene vs. Normal controls was evaluated on Presence of Ala67Thr mutation in PVR exon 2. The Ala67Thr mutation in the PVR gene was detected in 45.46% of patients with progressive post-polio syndrome compared to 10% of normal controls.
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