Key result
Elevated systolic blood pressure (≥161 mmHg) was associated with an increased risk of cancer mortality compared to the lowest quintile (RR 1.56; 95% CI 1.04-2.38), seen only in current smokers.
Why the study?
Is elevated blood pressure associated with an increased risk of cancer mortality in middle-aged men?
Population
7,735 middle-aged men drawn at random from one general practice in each of 24 British towns
Comparison
Elevated systolic and diastolic blood pressure vs Lower blood pressure quintiles
Design
Cohort
Follow-up
mean 12.75 years
Authors
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Finding limited to smokers is hypothesis-generating; should not alter BP management or inform cancer prevention.
Cohort (n=7,735)
Yes
Is elevated blood pressure associated with an increased risk of cancer mortality in middle-aged men?
Relative Risk: 1.56 (95% CI 1.04–2.38)
Elevated systolic blood pressure is associated with an increased risk of cancer mortality in middle-aged men, but this effect appears limited to current smokers.
Wannamethee et al. (1996) reported a cohort. Elevated systolic blood pressure (≥161 mmHg) vs. Bottom quintile of systolic blood pressure was evaluated on Cancer mortality (RR 1.56, 95% CI 1.04-2.38). Elevated systolic blood pressure (≥161 mmHg) was associated with an increased risk of cancer mortality compared to the lowest quintile (RR 1.56; 95% CI 1.04-2.38), seen only in current smokers.
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