Key result
Systolic BP over 150 mmHg linked to ~35% higher prostate cancer risk in older men.
Why the study?
It remained equivocal whether elevated blood pressure influences prostate cancer risk and survival.
Does elevated prediagnostic systolic and diastolic blood pressure increase the risk of incident prostate cancer and subsequent mortality?
Cohort (n=12,271)
No
Does elevated prediagnostic systolic and diastolic blood pressure increase the risk of incident prostate cancer and subsequent mortality?
Elevated prediagnostic systolic and diastolic blood pressure are associated with an increased risk of incident prostate cancer and higher overall mortality among men who develop the disease.
Answers are grounded in this paper and cite their sources.
May warrant vigilance for prostate cancer in hypertensive men >45; hypothesis-generating and should not yet change practice.
BACKGROUND: Inflammation has been linked to prostate cancer and hypertension, but it remains equivocal whether elevated blood pressure (BP) influence prostate cancer risk and survival. METHOD: Using Cox regression models, we examined the association between prediagnostic BP and prostate cancer risk among 12,271 men participating in the Prostate Cancer throughout life (PROCA-life) study. Systolic and diastolic BP were measured. A total of 811 men developed prostate cancer, and followed for additional 7.1 years, and we studied the association between prediagnostic BP and overall mortality among patients with prostate cancer. RESULTS: Men (>45 years) with a systolic BP >150 mmHg had a 35% increased risk of prostate cancer compared with men with a normal systolic BP (<130 mmHg) (HR 1.35, 95% CI 1.08-1.69). Among patients with prostate cancer, men with systolic BP >150 mmHg had a 49% increased overall mortality compared with men with a normal systolic BP (HR 1.49, 1.06-2.01). Among patients with prostate cancer treated with curative intent, those with a high diastolic BP (>90 mmHg) had a threefold increase in overall mortality risk (HR 3.01, 95% CI 1.40-6.46) compared with patients with a normal diastolic BP (<80 mmHg). CONCLUSION: Our results support that systolic and diastolic BP are important factors when balancing disease management in patients with prostate cancer.
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Stikbakke et al. (2021) conducted a cohort in Prostate Cancer (n=12,271). Elevated prediagnostic systolic blood pressure (>150 mmHg) vs. Normal systolic blood pressure (<130 mmHg) was evaluated on Incident prostate cancer in men >45 years (HR 1.35, 95% CI 1.08-1.69). Men older than 45 years with a prediagnostic systolic blood pressure >150 mmHg had a 35% increased risk of prostate cancer compared with men with a normal systolic BP (<130 mmHg).
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