Synthetic and Fermentation Type Chloramphenicol (Chloromycetin) in Typhoid Fever: Prevention of Relapses by Adequate Treatment

Article1 July 1950SYNTHETIC AND FERMENTATION TYPE CHLORAMPHENICOL (CHLOROMYCETIN) IN TYPHOID FEVER: PREVENTION OF RELAPSES BY ADEQUATE TREATMENTJOSEPH E. SMADEL, M.D., CHARLES A. BAILEY, M.D., RAYMOND LEWTHWAITE, M.D.JOSEPH E. SMADEL, M.D.Search for more papers by this author, CHARLES A. BAILEY, M.D.Search for more papers by this author, RAYMOND LEWTHWAITE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the efficacy of chloramphenicol (Chloromycetin†) in the treatment of typhoid fever is now well established,1-8there are many details which require further investigation. Accordingly, additional studies on the use of chloramphenicol in this disease were continued in Malaya by our group with the following purposes in view: (a) to compare the synthetic type of drug with the fermentation type which had been employed previously, (b) to determine the adequacy of treatment when given at various stages during the course of the disease, (c) to study the usefulness of simplified therapeutic regimens, and (d) to attempt to find means...Bibliography1. WoodwardSmadelLeyGreenMankikar TEJEHLRDS: Preliminary report on the beneficial effect of Chloromycetin in the treatment of typhoid fever, Ann. Int. Med. 29: 131-134, 1948. LinkGoogle Scholar2. WoodwardSmadelLey TEJEHL: Chloramphenicol and other antibiotics in the treatment of typhoid fever and typhoid carriers, J. Clin. Invest. 29: 87-99, 1950. CrossrefMedlineGoogle Scholar3. KnightRuiz-SanchezRuiz-SanchezShultzMcDermott VFASW: Antimicrobial therapy in typhoid, Arch. Int. Med. 85: 44-82, 1950. CrossrefGoogle Scholar4. Murgatroyd F: Typhoid treated with Chloromycetin, Brit. Med. J. 1: 851, 1949. CrossrefMedlineGoogle Scholar5. Bradley WH: Chloromycetin in typhoid fever, Lancet 1: 869, 1949. CrossrefMedlineGoogle Scholar6. Stiller R: Typhoid fever treated with Chloromycetin, J. Pediat. 35: 85-87, 1949. CrossrefMedlineGoogle Scholar7. CollinsFinland HSM: Treatment of typhoid fever with Chloromycetin; results in four cases and in a chronic carrier, New England J. Med. 241: 556-561, 1949. CrossrefMedlineGoogle Scholar8. ScarzellaMigazzoCappio MCM: Typhoid fever treated with aureomycin and chloramphenicol, Southern M. J. 42: 983-985, 1949. CrossrefMedlineGoogle Scholar9. Bartz QR: Isolation and characterization of Chloromycetin, J. Biol. Chem. 172: 445-450, 1948. CrossrefMedlineGoogle Scholar10. ControulisRebstockCrooks JMCHM: Chloramphenicol (Chloromycetin). V. Synthesis, J. Am. Chem. Soc. 71: 2463-2468, 1949. CrossrefGoogle Scholar11. SmadelJacksonLeyLewthwaite JEEBHLR: Comparison of synthetic and fermentation chloramphenicol (Chloromycetin) in rickettsial and viral infections, Proc. Soc. Exper. Biol. and Med. 70: 191-194, 1949. CrossrefMedlineGoogle Scholar12. LeySmadelCrocker HLJETT: Administration of Chloromycetin to normal human subjects, Proc. Soc. Exper. Biol. and Med. 68: 9-12, 1948. CrossrefMedlineGoogle Scholar13. StuartPullen BMRL: Typhoid; clinical analysis of 360 cases, Arch. Int. Med. 78: 629-661, 1946. CrossrefGoogle Scholar14. McCrae T: The symptoms of typhoid fever, Chapter IV in: Osler, W., and McCrae, T.: Modern medicine, Volume II, Infectious diseases, published by Lea Brothers and Company, Philadelphia, p. 104, 1907. Google Scholar15. Mallory FB: A histological study of typhoid fever, J. Exper. Med. 3: 611-638, 1898. CrossrefMedlineGoogle Scholar16. BaileyJumeaux CACV: Aureomycin in the treatment of peritonitis, Brit. M. J. 1: 271-273, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 19, 1949.From the Army Medical Department Research and Graduate School and the Commission on Immunization of the Army Epidemiological Board, Washington, D. C., and the Institute for Medical Research, Kuala Lumpur, Federation of Malaya.†Chloromycetin is a trade name of Parke, Davis and Company. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnteric fever: Resurrecting the epidemiologic footprintsCHEMOTHERAPY: THE LABORATORY ASSESSMENT OF NEW DRUGSTyphoid fever in African and Indian children in Durban.Management of Typhoid Fever and Its ComplicationsTHEODORE E. WOODWARD, M.D., F.A.C.P., JOSEPH E. SMADEL, M.D.SURGICAL TREATMENT OF ANGINA PECTORISBLOOD DYSCRASIAS ASSOCIATED WITH CHLORAMPHENICOLHYPNOSISTREATMENT OF TYPHOID FEVER WITH ANTIBIOTICSAntibacterial Agents in Gastrointestinal DiseaseTREATMENT OF TYPHOID FEVER. I. COMBINED THERAPY WITH CORTISONE AND CHLORAMPHENICOL*JOSEPH E. SMADEL, HERBERT L. LEY JR., FRED H. DIERCKS 1 July 1950Volume 33, Issue 1Page: 1-17KeywordsArmed forcesChloramphenicolDrug synthesisDrugsGraduate medical educationTyphoid ePublished: 1 December 2008 Issue Published: 1 July 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...