Why the study?
Does inhibition of thromboxane synthase reduce malonaldehyde and thromboxane B2 secretion in human platelets?
Population
Gel-filtered suspensions of human platelets
Design
Preclinical
Authors
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Supports thromboxane dependence of platelet degranulation in animals; leaves open translation to human platelets and clinical inhibition.
Does inhibition of thromboxane synthase reduce malonaldehyde and thromboxane B2 secretion in human platelets?
Thromboxane synthase catalyzes malonaldehyde formation in intact platelets, and platelet degranulation depends primarily on thromboxane production rather than prostaglandin endoperoxides.
McMillan et al. (1978) studied this question.
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