Key result
Angina symptoms in women without obstructive CAD were associated with lower median CFVR than in asymptomatic women (2.33 vs 2.60; p=0.007), but the difference disappeared after risk factor adjustment.
Why the study?
Coronary microvascular dysfunction (CMD) is considered to cause angina pectoris in women with no obstructive CAD, but data supporting a relation between angina and CMD are limited.
Is impaired coronary flow velocity reserve associated with angina symptoms and cardiovascular risk factors in women with no obstructive coronary artery disease?
Population
1684 women with angina and <50% coronary stenosis plus 102 asymptomatic reference women
Comparison
Women with angina vs asymptomatic women
Design
Cross-sectional study
Authors
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CFVR-symptom association vanishes after risk-factor adjustment; leaves open independent microvascular role in angina and should not yet change practice.
Cross-Sectional (n=1,786)
Is impaired coronary flow velocity reserve associated with angina symptoms and cardiovascular risk factors in women with no obstructive coronary artery disease?
Absolute Event Rate: 2.33% vs 2.6%
p-value: p=0.007
Impaired coronary flow velocity reserve in women with no obstructive CAD is driven by cardiovascular risk factors rather than being independently associated with angina symptoms, questioning the current concept of microvascular angina.
Bove et al. (2021) conducted a cross-sectional in Angina with no obstructive coronary artery disease (n=1,786). Angina symptoms vs. Asymptomatic women was evaluated on Median coronary flow velocity reserve (CFVR) (p=0.007). Angina symptoms in women without obstructive CAD were associated with lower median CFVR than in asymptomatic women (2.33 vs 2.60; p=0.007), but the difference disappeared after risk factor adjustment.
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