January 1, 2017Journal of Vascular Research

Flow-mediated dilation and biomarkers of endothelial dysfunction did not correlate with coronary flow velocity reserve (Spearman ρ = -0.07, p = 0.45) in women with angina and no obstructive CAD.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Angina and no obstructive coronary artery disease (n=219). Intervention: Impaired flow-mediated dilation (FMD) and plasma biomarkers. Primary outcome: Correlation between coronary flow velocity reserve (CFVR) and flow-mediated dilation (FMD) (Spearman ρ = -0.07, p=0.45).

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Why the study?

Are impaired flow-mediated dilation and plasma biomarkers associated with coronary microvascular dysfunction in women with angina and no obstructive CAD?

Population

194 women with angina pectoris and no obstructive CAD and a reference population of 25 asymptomatic women…

Comparison

Measurement of flow-mediated dilation in the… vs Asymptomatic women without CAD and internal…

Design

Cross-sectional

Key result

Flow-mediated dilation and biomarkers of endothelial dysfunction did not correlate with coronary flow velocity reserve (Spearman ρ = -0.07, p = 0.45) in women with angina and no obstructive CAD.

Authors

KRKristoffer Flintholm Raft DFDaria Frestad MMMarie Mide Michelsen

Discussion

Member takes

Overview

Peripheral FMD testing should not substitute for coronary assessment in INOCA; leaves open distinct endothelial pathways.

Study Design

Type

Cross-Sectional (n=219)

Structured PICO

Are impaired flow-mediated dilation and plasma biomarkers associated with coronary microvascular dysfunction in women with angina and no obstructive CAD?

Population

219 women (194 with angina and no obstructive CAD, 25 asymptomatic controls) assessed for the association between peripheral endothelial function and coronary microvascular dysfunction.

Exposure

Measurement of flow-mediated dilation (FMD) in the brachial artery by high-resolution ultrasound and endothelial plasma biomarkers

Comparator

Asymptomatic women without CAD (reference population) and internal comparison based on coronary flow velocity reserve (CFVR) status

Outcome

Association between peripheral endothelial dysfunction (FMD and plasma biomarkers) and coronary microvascular dysfunction (CFVR <2 assessed by TTDE)surrogate

Main Result

Effect estimate: Spearman ρ = -0.07

p-value: p=0.45

Peripheral endothelial function assessed by FMD does not correlate with coronary microvascular dysfunction in women with INOCA, indicating peripheral testing cannot substitute for coronary flow assessment.

Cite This Study

Raft et al. (2017) conducted a cross-sectional in Angina and no obstructive coronary artery disease (n=219). Impaired flow-mediated dilation (FMD) and plasma biomarkers was evaluated on Correlation between coronary flow velocity reserve (CFVR) and flow-mediated dilation (FMD) (Spearman ρ = -0.07, p=0.45). Flow-mediated dilation and biomarkers of endothelial dysfunction did not correlate with coronary flow velocity reserve (Spearman ρ = -0.07, p = 0.45) in women with angina and no obstructive CAD.

synapsesocial.com/papers/6ab3770e23dc4f8dac45cde0 https://doi.org/10.1159/000479374

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January 1, 2017Journal of Vascular Research

Flow-mediated dilation and biomarkers of endothelial dysfunction did not correlate with coronary flow velocity reserve (Spearman ρ = -0.07, p = 0.45) in women with angina and no obstructive CAD.

View Full Paper

Ask AI

Bookmark

Why the study?

Are impaired flow-mediated dilation and plasma biomarkers associated with coronary microvascular dysfunction in women with angina and no obstructive CAD?

Population

194 women with angina pectoris and no obstructive CAD and a reference population of 25 asymptomatic women…

Comparison

Measurement of flow-mediated dilation in the… vs Asymptomatic women without CAD and internal…

Design

Cross-sectional

Key result

Flow-mediated dilation and biomarkers of endothelial dysfunction did not correlate with coronary flow velocity reserve (Spearman ρ = -0.07, p = 0.45) in women with angina and no obstructive CAD.

Authors

KRKristoffer Flintholm Raft DFDaria Frestad MMMarie Mide Michelsen

Discussion

Member takes

Overview

Peripheral FMD testing should not substitute for coronary assessment in INOCA; leaves open distinct endothelial pathways.

Study Design

Type

Cross-Sectional (n=219)

Structured PICO

Are impaired flow-mediated dilation and plasma biomarkers associated with coronary microvascular dysfunction in women with angina and no obstructive CAD?

Population

219 women (194 with angina and no obstructive CAD, 25 asymptomatic controls) assessed for the association between peripheral endothelial function and coronary microvascular dysfunction.

Exposure

Measurement of flow-mediated dilation (FMD) in the brachial artery by high-resolution ultrasound and endothelial plasma biomarkers

Comparator

Asymptomatic women without CAD (reference population) and internal comparison based on coronary flow velocity reserve (CFVR) status

Outcome

Association between peripheral endothelial dysfunction (FMD and plasma biomarkers) and coronary microvascular dysfunction (CFVR <2 assessed by TTDE)surrogate

Main Result

Effect estimate: Spearman ρ = -0.07

p-value: p=0.45

Cite This Study

synapsesocial.com/papers/6ab3770e23dc4f8dac45cde0 https://doi.org/10.1159/000479374

View Full Paper

Ask AI

Bookmark