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January 1, 2016Journal of Cardiovascular Magnetic ResonanceOpen Access

Coronary microvascular function and myocardial fibrosis in women with angina pectoris and no obstructive coronary artery disease: the iPOWER study

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Population

64 women with angina-like chest pain, no significant obstructive CAD, and no diabetes, mean age 62.5 years.

Design

Cross-sectional, Independent observers performed all analyses blinded to…

Authors

NMNaja Dam MygindUniversity of CopenhagenMMMarie Mide MichelsenNovo Nordisk (Denmark)APAdam PeñaUniversity of Southern California

Discussion

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Implication

No association between microvascular dysfunction and fibrosis in women with angina and no CAD; hypothesis-generating and requires longitudinal confirmation.

Structured PICO

P
Population
64 women with angina-like chest pain, no significant obstructive CAD (<50% stenosis on coronary angiogram), and no diabetes, mean age 62.5 years.
I
Intervention
Assessment of coronary microvascular dysfunction using transthoracic Doppler echocardiography (CFVR with dipyridamole) and positron emission tomography (MBFR with adenosine)
O
Outcome
Diffuse myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) T1 mapping (native T1 and extracellular volume fraction [ECV])surrogate

In women with angina and no obstructive coronary artery disease, coronary microvascular dysfunction is not associated with diffuse myocardial fibrosis, suggesting ischemia in this population does not elicit fibrosis.

Limitations

  • Small study sample size

Cite This Study

Mygind et al. (2016) studied this question.

synapsesocial.com/papers/6a7f72d1024876978df6d9d6https://doi.org/10.1186/s12968-016-0295-5

Topics

Coronary artery diseaseCardiac MRICoronary CT angiographyWomen and heart disease
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