Key result
Circulating miR-185-5p was significantly upregulated in patients with arrhythmogenic right ventricular cardiomyopathy, yielding a diagnostic area under the curve of 0.854.
Why the study?
Diagnosis of ARVC is challenging and often achieved only after disease onset or postmortem, motivating the search for circulating microRNA biomarkers.
Does circulating miR-185-5p serve as an accurate diagnostic biomarker for arrhythmogenic right ventricular cardiomyopathy compared to healthy controls?
Case-Control (n=108)
Does circulating miR-185-5p serve as an accurate diagnostic biomarker for arrhythmogenic right ventricular cardiomyopathy compared to healthy controls?
Effect estimate: AUC 0.854
Circulating miR-185-5p is significantly upregulated in ARVC and demonstrates high diagnostic accuracy, suggesting its potential as a non-invasive biomarker for the disease.
May support ARVC diagnosis; hypothesis-generating and should not change practice without prospective validation.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease characterized by progressive myocardial fibro-fatty replacement, arrhythmias and risk of sudden death. Its diagnosis is challenging and often it is achieved after disease onset or postmortem. In this study, we sought to identify circulating microRNAs (miRNAs) differentially expressed in ARVC patients compared to healthy controls. In the pilot study, we screened the expression of 754 miRNAs from 21 ARVC patients and 20 healthy controls. After filtering the miRNAs considering a log fold-change cut-off of ±1, p-value < 0.05, we selected five candidate miRNAs for a subsequent validation study in which we used TaqMan-based real-time PCR to analyse samples from 37 ARVC patients and 30 healthy controls. We found miR-185-5p significantly upregulated in ARVC patients. Receiver operating characteristic analysis indicated an area under the curve of 0.854, corroborating the link of this miRNA and ARVC pathophysiology.
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Sacchetto et al. (2021) conducted a case-control in Arrhythmogenic right ventricular cardiomyopathy (ARVC) (n=108). Arrhythmogenic right ventricular cardiomyopathy (ARVC) vs. Healthy controls was evaluated on Diagnostic accuracy of circulating miR-185-5p (AUC 0.854). Circulating miR-185-5p was significantly upregulated in patients with arrhythmogenic right ventricular cardiomyopathy, yielding a diagnostic area under the curve of 0.854.
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