Key result
Admission glucose in patients hospitalized with acute STEMI was significantly associated with elevated inflammatory plasma proteins, particularly in non-diabetic patients.
Why the study?
The study was conducted to investigate the association between admission glucose and HbA1c values and inflammatory plasma proteins in hospitalized patients with acute STEMI.
Observational (n=345)
No
Stress hyperglycemia at admission in STEMI patients, particularly those without known diabetes, is significantly associated with an acute inflammatory response involving multiple cytokines and chemokines.
Answers are grounded in this paper and cite their sources.
Admission glucose linked to inflammatory proteins mainly in non-diabetic STEMI; hypothesis-generating for stress hyperglycemia, needs prospective validation.
BACKGROUND: To investigate the association between admission glucose and HbA1c values and inflammatory plasma proteins in hospitalized patients with acute ST-elevation myocardial infarction (STEMI). METHODS: This analysis was based on 345 STEMI patients recorded by the population-based Myocardial Infarction Registry Augsburg between 2009 and 2013. Using the OLINK inflammatory panel, a total of 92 protein biomarkers were measured in arterial blood samples, which were obtained within the scope of cardiac catheterization immediately after admission. The associations between admission glucose and HbA1c levels and the 92 protein markers were investigated using multivariable linear regression models. RESULTS: Admission glucose showed significantly positive associations with the inflammatory markers IL-10, IL-8, IL-6, FGF-21, IL-7, ST1A1, MCP-1, 4E-BP1, SIRT2, STAMBP and IL-18R1 after Bonferroni adjustment. HbA1c values were only significantly associated with IL-18R1. In stratified analyses, admission glucose was not significantly associated with any plasma protein in the diabetes subgroup, while there were several protein markers that showed significantly positive associations with admission glucose in STEMI patients without known diabetes, namely IL-10, CCL20, IL-8, MCP-1 and IL-6. CONCLUSIONS: Admission glucose in patients hospitalized due to an acute STEMI seems to be related to an inflammatory and immune-related response, expressed by an increase in inflammation-related plasma proteins in particular in non-diabetic patients with stress hyperglycemia. The present results may open new avenues for the development of biomarkers suitable as potential diagnostic or prognostic clinical markers.
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Christa et al. (2025) conducted an observational in Acute ST-elevation myocardial infarction (STEMI) (n=345). Admission glucose and HbA1c levels was evaluated on Association between admission glucose/HbA1c and 92 inflammatory plasma proteins. Admission glucose in patients hospitalized with acute STEMI was significantly associated with elevated inflammatory plasma proteins, particularly in non-diabetic patients.
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