Highlights that superior vena cava syndrome can be caused by metastatic breast carcinoma, reflecting a shift towards malignant etiologies for this syndrome.
Metastatic breast carcinoma merits consideration in SVC syndrome; case reports leave the shift to malignant etiologies hypothesis-generating.
Two women with the superior vena cava syndrome caused by biopsy-proven metastatic breast carcinoma are reported in spite of the high incidence of breast carcinoma and the high incidence of metastasis to mediastinal lymph nodes, a review of the literature yields only 3 similar cases the superior vena cava syndrome, formerly chiefly caused by inflammatory lesions, is now much more often associated with malignant tumors.
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White et al. (1970) studied this question.
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