Perforation of chronic peptic ulcers after cimetidine.

form of treatment on cardiovascular morbidity and mortality.Although disappointing, this is not altogether surprising in view of the overwhelming preponderance of the blood pressure level as the major risk factor for cardiovascular morbidity and mortality in this group.Some workers have found that the blood pressure is a more significant risk factor for arterial disease among established diabetics than among non-diabetics. 15 Possibly hypotensive treatment should therefore be more readily used in people who also have glucose intolerance or diabetes.The only other conventional risk factor which also had some predictive power in borderline diabetics was the plasma cholesterol concentration.The implication of this finding is that diets aimed at lowering plasma cholesterol might be more appropriate than simply low-carbohydrate or low-calorie diets, as we have discussed more fully elsewhere.'The study and our participation in the Whitehall survey was financed by a grant from the Department of Health and Social Security.M McCartney is