Population
Mice and continuous cell lines
Comparison
Diabetogenic strain of encephalomyocarditis… vs Different cell lines used for virus propagation…
Design
Preclinical
Authors
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Suggests propagation conditions alter viral traits in animal diabetes models; leaves open human relevance and requires prospective validation.
The diabetogenic and interferon-inducing characteristics of the encephalomyocarditis virus are unstable and depend on the cell line used for propagation and insulin presence.
Giron et al. (1982) studied this question.
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