Key result
Stratification by family history of stroke in hypertensive sibpairs revealed linkage heterogeneity (LOD ≥1.5), suggesting shared susceptibility genes on chromosome 13 in whites and 19 in blacks.
Why the study?
Does family history of stroke influence genetic linkage patterns for hypertension susceptibility in black and white sibships?
Observational (n=603)
Yes
Does family history of stroke influence genetic linkage patterns for hypertension susceptibility in black and white sibships?
Genome-wide linkage scans identified specific chromosomal regions (chromosomes 13 in whites and 19 in blacks) that may harbor shared susceptibility genes for both hypertension and stroke.
Should not alter hypertension or stroke management; leaves open race-specific genetic linkages for future replication.
BACKGROUND AND PURPOSE: Hypertension is an important risk factor for stroke, and the 2 diseases may share susceptibility genes in common. We sought to identify genomic regions influencing susceptibility to both hypertension and stroke. SUBJECTS AND METHODS: Genome-wide linkage scans were performed in samples of 338 white and 265 black hypertensive sibships recruited by the Genetic Epidemiology Network of Arteriopathy Study of the NHLBI Family Blood Pressure Program (FBPP). The hypertensive sibships were stratified by positive (+FH) or negative (-FH) family history of stroke. Genome-wide scans were repeated in each stratum, and the results were compared within each ethnic group by a regression-based analysis of heterogeneity. RESULTS: In whites, the best evidence for linkage was found on chromosome 16 in the unstratified sample of hypertensive sibpairs (logarithm of odds [LOD]=1.85 at 71 cM). In blacks, the best evidence for linkage was found on chromosome 2 in the unstratified sample of hypertensive sibpairs (LOD=1.95 at 230 cM). Additional evidence for linkage (LOD >or=1.5) was observed among white hypertensive sibpairs with a -FH on chromosome 13 and among black hypertensive sibpairs with a +FH of stroke on chromosome 19. CONCLUSIONS: Significant evidence for linkage heterogeneity among hypertensive sibpairs stratified by family history of stroke suggests the presence of genes influencing susceptibility to both hypertension and stroke on chromosomes 13 (whites) and 19 (blacks). Although no significant evidence of heterogeneity was observed on chromosome 16 in whites and chromosome 2 in blacks, these chromosomes do provide evidence of linkage to hypertension.
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Morrison et al. (2003) conducted an observational in Hypertension (n=603). Family history of stroke vs. Negative family history of stroke was evaluated on Genome-wide linkage (LOD score). Stratification by family history of stroke in hypertensive sibpairs revealed linkage heterogeneity (LOD ≥1.5), suggesting shared susceptibility genes on chromosome 13 in whites and 19 in blacks.
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