Key result
Having ≥5 ideal cardiovascular health metrics was associated with a lower prevalence of retinopathy compared to having zero ideal metrics (2.1% vs 13.1%; OR 4.8, 95% CI 2.5-8.9).
Why the study?
Is a higher number of ideal cardiovascular health metrics associated with a lower prevalence of retinopathy and more favorable retinal microvascular diameters?
Observational
Is a higher number of ideal cardiovascular health metrics associated with a lower prevalence of retinopathy and more favorable retinal microvascular diameters?
Odds Ratio: 4.8 (95% CI 2.5–8.9)
Absolute Event Rate: 2.1% vs 13.1%
A higher number of ideal cardiovascular health metrics is associated with a lower prevalence of retinopathy and more favorable retinal microvascular diameters, which are markers for subclinical cerebrovascular disease.
Should not yet change retinopathy screening; extends observational links between ideal CVH metrics and retinal microvascular health.
BACKGROUND: This study evaluated the prevalence of ideal cardiovascular (CV) health in the Atherosclerosis Risk in Communities Study and determined its relationship with prevalent retinopathy, wider retinal venular diameters, and narrower arteriolar diameters, which are risk markers for subclinical cerebrovascular disease and are associated with increased stroke and coronary heart disease (CHD) morbidity and mortality. METHODS AND RESULTS: We used gradings of fundus photography measurements from the Atherosclerosis Risk in Communities Study to examine the association of retinopathy and retinal arteriolar and venular calibers to the number of ideal CV health metrics. Prevalent retinopathy showed a graded relationship with the CV health categories and number of ideal CV health metrics present: retinopathy prevalence was 2.1% among those with ≥5 ideal CV health metrics compared with 13.1% among those with zero ideal CV health metrics (odds ratio [CI]), 4.8 [2.5 to 8.9]). Central retinal venule equivalent and central retinal arteriolar equivalent diameters also showed graded relationships with CV health categories and number of ideal CV health metrics: after adjustment for age, race, sex, and education, mean central retinal venular equivalent was 187.8 μm (95% CI, 186.9 to 188.6 μm) among those with ≥5 ideal CV health metrics compared with 201.1 μm (95% CI, 199.1 to 203.1 μm) among those with zero ideal CV health metrics. Mean central retinal arteriolar equivalent was 163.8 μm (95% CI, 163.0 to 164.5 μm) among those with ≥5 ideal CV health metrics compared with 157.9 μm (95% CI, 156.1 to 159.7 μm) among those with zero ideal CV health metrics. CONCLUSIONS: Few adults had ideal cardiovascular health. Those with the best level of health were less likely to have retinopathy signs, wide retinal venules, and narrow retinal arterioles, which are associated with increased stroke and coronary heart disease risk.
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Ogagarue et al. (2013) conducted an observational in Cardiovascular health. ≥5 ideal cardiovascular health metrics vs. Zero ideal cardiovascular health metrics was evaluated on Prevalent retinopathy (OR 4.8, 95% CI 2.5 to 8.9). Having ≥5 ideal cardiovascular health metrics was associated with a lower prevalence of retinopathy compared to having zero ideal metrics (2.1% vs 13.1%; OR 4.8, 95% CI 2.5-8.9).
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