The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia

William A. Leonard

doi:10.1001/archinte.1958.00260160036005

April 1, 1958Archives of Internal Medicine

The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia

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Why the study?

Does diphenylhydantoin sodium treat ventricular tachycardia in patients with acute myocardial infarction?

Key Points

Assess the clinical utility of diphenylhydantoin (Dilantin) sodium for controlling ventricular tachycardia following acute myocardial infarction.
Reviewed clinical observations of ventricular arrhythmias emerging after acute myocardial infarction and during digitalis administration.
Evaluated pharmacologic suppression of ventricular ectopic activity in coronary artery ligation models using central nervous system depressants.
Ventricular tachycardia manifests as a severe complication in approximately 2% of acute myocardial infarction cases, predominantly within the initial 5 days.
Diphenylhydantoin sodium successfully terminates ventricular ectopic activity induced by anterior descending coronary artery ligation.

Structured PICO

Does diphenylhydantoin sodium treat ventricular tachycardia in patients with acute myocardial infarction?

P

Population

Patients with ventricular tachycardia complicating acute myocardial infarction

I

Intervention

Diphenylhydantoin sodium

The text introduces the rationale for using diphenylhydantoin sodium to treat ventricular tachycardia in the setting of acute myocardial infarction.

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Implication

Introduces rationale for diphenylhydantoin sodium in AMI-related VT; hypothesis-generating and requires prospective validation before clinical use.

Abstract

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Cite This Study

William A. Leonard (1958) studied this question.

synapsesocial.com/papers/6a9480df238f27b4d12ddc96 https://doi.org/10.1001/archinte.1958.00260160036005

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The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular Tachycardia

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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