Why the study?
Do bismuth salts inhibit plaque formation of enteric viruses in vitro?
Do bismuth salts inhibit plaque formation of enteric viruses in vitro?
Bismuth salts inhibit enteric virus plaque formation in vitro, likely due to interference with host cell functions rather than direct virucidal effects.
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In vitro bismuth inhibition does not support clinical use against enteric viruses; leaves open mechanistic and in vivo studies.
Bismuth salts inhibited plaque formation of all enteric viruses tested, which included four strains of rotavirus and one strain each of echovirus, reovirus, and poliovirus. The compounds had no direct virucidal effect at concentrations ranging from 0.025 to 2.5 mg/ml, and the inhibitory effects were observed only at concentrations slightly below those that caused extensive cytotoxicity. Plaque inhibition appeared to result from interference with host cell functions, with secondary inhibition of virus production.
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Ward et al. (1985) studied this question.
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