Why the study?
What is the recurrence risk of congenital cardiovascular malformations in children having one parent with congenital heart disease?
What is the recurrence risk of congenital cardiovascular malformations in children having one parent with congenital heart disease?
The risk of congenital heart disease recurrence in offspring of an affected parent is 2.5% to 4.3%, typically manifesting as the same or a closely related lesion.
Supports counseling of parents with CHD on offspring risks; extends observational data but leaves open generalizability and modifiers.
The risk of recurrence of a congenital cardiovascular malformation in a child having one parent with congenital heart disease has been determined for each of the seven most common anomalies presently compatible with survival to reproductive age. The range of risk is 2.5% to 4.3% depending on the lesion. This is within the range of expectation for the model of multifactorial inheritance previously used to predict recurrence in other first-degree relatives of probands (siblings and parents) with congenital heart disease. The cardiovascular abnormality occurring in the child was most often the same as in the parent or was a closely related variant of it.
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Nora et al. (1976) studied this question.
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