Key result
Parental consanguinity was not significantly associated with the incidence of congenital heart disease among siblings (p=0.169), whereas having an older sibling with the disease increased the risk for the younger sibling.
Why the study?
To determine the frequency and types of congenital heart disease between siblings in Central Anatolia and investigate the contribution of consanguineous marriages.
Does consanguinity increase the incidence of congenital heart disease in children?
Observational (n=1,916)
No
Does consanguinity increase the incidence of congenital heart disease in children?
p-value: p=0.169
While consanguinity was not significantly associated with CHD incidence, having an older sibling with CHD increases the risk for younger siblings.
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Supports family history-based CHD screening in siblings; leaves open the contribution of parental consanguinity.
Yılmaz et al. (2023) conducted an observational in Congenital heart disease (n=1,916). Parental consanguinity vs. Non-consanguineous parents was evaluated on Presence of congenital heart disease in any sibling (p=0.169). Parental consanguinity was not significantly associated with the incidence of congenital heart disease among siblings (p=0.169), whereas having an older sibling with the disease increased the risk for the younger sibling.
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