Key result
Consanguinity was present in 62% of families with congenital heart disease and was associated with exclusively concordant cardiac lesions and a higher prevalence of dilated cardiomyopathy.
Why the study?
Does consanguinity influence the pattern of familial aggregation of congenital heart disease?
Observational (n=93)
No
Does consanguinity influence the pattern of familial aggregation of congenital heart disease?
Consanguinity is highly prevalent in familial congenital heart disease in Saudi Arabia and is associated with concordant cardiac lesions and a higher prevalence of dilated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
May inform risk counseling in consanguineous families; leaves open causality and generalizability pending prospective studies.
Seliem et al. (2006) conducted an observational in Congenital heart disease (n=93). Consanguinity vs. Non-consanguineous marriage was evaluated on Concordance of cardiac lesions and prevalence of dilated cardiomyopathy. Consanguinity was present in 62% of families with congenital heart disease and was associated with exclusively concordant cardiac lesions and a higher prevalence of dilated cardiomyopathy.
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