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August 21, 2025

Retrospective Analysis of Congenital Heart Disease in Saudi Arabian Children Born to Consanguineous Parents: Outcomes and Risk Factors from 2021 to 2025

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CHD prevalence was 8.7 per 1000 live births, increasing to 12.3 per 1000 among first-cousin unions, indicating a strong link to consanguinity.
Pathogenic variants in NKX2.5, GATA4, and TBX5 significantly raised CHD risk, emphasizing the role of genetic mutations in disease development.
A retrospective cohort analysis was conducted involving 7842 children across 14 tertiary care centers, examining factors related to CHD outcomes.
Improving genetic counseling and implementing early surgical interventions may significantly enhance outcomes for children born with CHD in high-risk populations.

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Retrospective cohort study shows increased CHD risk and prevalence in Saudi children, highlighting impacts of genetic factors and consanguinity.

Alhashim et al. (2025) studied this question.

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Retrospective cohort study shows increased CHD risk and prevalence in Saudi children, highlighting impacts of genetic factors and consanguinity.