Key result
The frequency of protein C and protein S deficiencies in Japanese patients with deep venous thrombosis was 15.6 and 7.38 times higher than in the control population, respectively (P < 0.05).
Why the study?
What is the frequency of natural coagulation inhibitor deficiencies in Japanese patients with DVT compared to normal subjects?
Population
113 consecutive Japanese patients with deep venous thrombosis (DVT) and 392 normal Japanese subjects
Design
Case-control
Authors
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Japanese DVT patients had markedly higher protein C/S deficiency rates; leaves open whether screening improves outcomes in this population.
Case-Control (n=505)
What is the frequency of natural coagulation inhibitor deficiencies in Japanese patients with DVT compared to normal subjects?
Absolute Event Rate: 28.3% vs 2.55%
p-value: p=< 0.05
Japanese patients with DVT have a significantly higher frequency of protein C and protein S deficiencies compared to the normal population, suggesting a need for routine screening.
Suehisa et al. (2001) conducted a case-control in Deep venous thrombosis (n=505). Deep venous thrombosis (DVT) vs. Normal subjects was evaluated on Frequency of antithrombin III, protein C, and protein S deficiencies (p=< 0.05). The frequency of protein C and protein S deficiencies in Japanese patients with deep venous thrombosis was 15.6 and 7.38 times higher than in the control population, respectively (P < 0.05).
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