Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2016Laboratory Animal ResearchOpen Access

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

View Full Paper
Ask AI
Bookmark
Share

Key result

Fermented red ginseng significantly reduced serum total cholesterol by up to 57.3% and triglycerides by 82.4% compared to a high-fat diet control in rats.

Why the study?

Does fermented red ginseng improve lipid profiles and protect against liver injury in rats on a high-fat diet?

Population

Sprague-Dawley rats on a high-fat diet (n=28, divided into 4 groups of 7)

Comparison

Fermented red ginseng 0.5% or 1% in drinking… vs High-fat diet control and normal control

Design

Preclinical

Follow-up

8 weeks

Authors

MKMyeonghwan KimELEun-Jin LeeJCJeong-Mu Cheon

Discussion

Loading...

Member takes

Overview

Does not support clinical use; leaves open translation of lipid effects to human hyperlipidemia.

Structured PICO

Does fermented red ginseng improve lipid profiles and protect against liver injury in rats on a high-fat diet?

P
Population
28 adult male Sprague-Dawley rats with high-fat diet-induced hyperlipidemia were treated with fermented red ginseng for 8 weeks.
I
Intervention
Fermented red ginseng (FRG) 0.5% or 1% in drinking water for 8 weeks
C
Comparator
High-fat diet control (HFC) and normal control (NC)
O
Outcome
Serum levels of ALT, AST, TC, TG, LDL-C, HDL-C, hepatic oxidative stress markers (MDA, SOD, CAT, GSH-Px), and liver histology at 8 weekssurrogate

Main Result

p-value: p=<0.05

Fermented red ginseng improves lipid profiles and provides hepatoprotection against oxidative stress in a rat model of high-fat diet-induced hyperlipidemia.

Cite This Study

Kim et al. (2016) studied High-fat diet-induced hyperlipidemia (n=28). Fermented red ginseng vs. High-fat diet control was evaluated on Serum total cholesterol (p=<0.05). Fermented red ginseng significantly reduced serum total cholesterol by up to 57.3% and triglycerides by 82.4% compared to a high-fat diet control in rats.

synapsesocial.com/papers/6a94c6c591e044666ef2eb98https://doi.org/10.5625/lar.2016.32.4.217
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-hyperlipidemic Effects of Red Ginseng Acidic Polysaccharide from Korean Red Ginseng2010 · 95 citations
  2. 2Role of oxidative stress in cardiovascular diseases2000 · 1,469 citations
  3. 3Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice2013 · 63 citations
  4. 4American Ginseng Berry Juice Intake Reduces Blood Glucose and Body Weight in ob / ob Mice2007 · 60 citations
  5. 5Oral Antihyperglycemic Therapy for Type 2 Diabetes2002 · 1,069 citations