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Aldehydes are converted into ( E )- α, β -unsaturated carboxylic acids using C, O, O -tris(trimethylsilyl)ketene acetal 1 . This organosilicon reagent is easily generated from trimethylsilyl acetate, LDA, and chlorotrimethylsilane. The effectiveness of the reaction has been explored for a large variety of aldehydes with Lewis acids and fluorides as catalysts.
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Bellassoued et al. (1998) studied this question.
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