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Bleomycin is an important antibiotic for the treatment of cancer. Now the completion of the total synthesis of the aglycon 1 from bleomycin A2, the major component of bleomycin, has been achieved. The decisive steps are the construction of the pyrimidine part by an inverse-electron-demand Diels–Alder reaction and the diastereoselective addition of a stannous enolate to an imine group.
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Boger et al. (1993) studied this question.
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